#4027 KIDNEY INJURY MOLECULE 1 (KIM-1): A POTENTIAL BIOMARKER OF ACUTE KIDNEY INJURY AND TUBULOINTERSTITIAL INJURY IN PATIENTS WITH ANCA-GLOMERULONEPHRITIS
نویسندگان
چکیده
Abstract Background and Aims Kidney injury molecule 1 (KIM-1) is a transmembrane glycoprotein expressed by proximal tubular cells, recognized as an early, sensitive, specific urinary biomarker for kidney injury. Blood KIM-1 was recently associated with the severity of acute chronic damage but its value in ANCA-associated vasculitis glomerulonephritis (ANCA-GN) has not been studied. Thus, we analyzed expression at ANCA-GN diagnosis relationship clinical presentation, histopathology, early outcomes. Method We assessed levels other pro-inflammatory molecules (CRP, IL-6, TNF-α, MCP-1 PTX3) after 6 months patients included Maine-Anjou registry, which gathers data from four French Nephrology Centers diagnosed since January 2000. Results were 58 patients. Levels elevated decreased induction remission therapy. renal need KRT. In opposition to molecules, correlated amount interstitial fibrosis atrophy (IF/TA) on biopsy, glomerular involvement. multivariable analysis, predicted initial eGFR (β = -19 [-31, -7.6], p 0.002). Conclusion appears potential tubulointerstitial ANCA-GN. Whether only surrogate marker IF/TA or key immune player pathogenesis remain be determined.
منابع مشابه
Kidney injury molecule-1 (KIM-1): a novel kidney-specific injury molecule playing potential double-edged functions in kidney injury.
Kidney injury molecule-1 (KIM-1), a recently discovered transmembrane protein, is expressed in dedifferentiated proximal renal tubular epithelial cells in damaged regions. It may participate in the progress of renal injury or repair. Many studies have illustrated the different functions of KIM-1 in various renal diseases including protective functions in acute kidney injury and damaging functio...
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Urinary kidney injury molecule-1 (Kim-1): a sensitive quantitative biomarker for early detection of kidney tubular injury
Sensitive and specific biomarkers are needed to detect early kidney injury. The objective of the present work was to develop a sensitive quantitative urinary test to identify renal injury in the rodent to facilitate early assessment of pathophysiological influence and drug toxicity. Two mouse monoclonal antibodies were made against the purified ectodomain of kidney injury molecule-1 (Kim-1) and...
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1. Kellum JA, Bellomo R, Ronco C et al. The 3rd International consensus conference of the acute dialysis quality initiative (ADQI). Int J Artif Organs 2005; 28: 441–444 2. Mehta RL, Chertow GM. Acute renal failure definitions and classification: time for change? J Am Soc Nephrol 2003; 14: 2178–2187 3. Smith HW. The Kidney: Structure and Function in Health and Disease. New York: Oxford Universit...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2023
ISSN: ['1460-2385', '0931-0509']
DOI: https://doi.org/10.1093/ndt/gfad063c_4027